Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity

The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across ten newly generated as well as fo...

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Udgivet i:PLoS Comput Biol
Main Authors: Bassani-Sternberg, Michal, Chong, Chloé, Guillaume, Philippe, Solleder, Marthe, Pak, HuiSong, Gannon, Philippe O., Kandalaft, Lana E., Coukos, George, Gfeller, David
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584980/
https://ncbi.nlm.nih.gov/pubmed/28832583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005725
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