TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures

Cholangiocarcinoma (CCA) and its subtypes (mucin- and mixed-CCA) arise from the neoplastic transformation of cholangiocytes, the epithelial cells lining the biliary tree. CCA has a high mortality rate owing to its aggressiveness, late diagnosis and high resistance to radiotherapy and chemotherapeuti...

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Publicado en:PLoS One
Main Authors: Lustri, Anna Maria, Di Matteo, Sabina, Fraveto, Alice, Costantini, Daniele, Cantafora, Alfredo, Napoletano, Chiara, Bragazzi, Maria Consiglia, Giuliante, Felice, De Rose, Agostino M., Berloco, Pasquale B., Grazi, Gian Luca, Carpino, Guido, Alvaro, Domenico
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584931/
https://ncbi.nlm.nih.gov/pubmed/28873435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183932
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