CD18 deficiency improves liver injury in the MCD model of steatohepatitis

Neutrophils and macrophages are important constituents of the hepatic inflammatory infiltrate in non-alcoholic steatohepatitis. These innate immune cells express CD18, an adhesion molecule that facilitates leukocyte activation. In the context of fatty liver, activation of infiltrated leukocytes is b...

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Veröffentlicht in:PLoS One
Hauptverfasser: Pierce, Andrew A., Duwaerts, Caroline C., Siao, Kevin, Mattis, Aras N., Goodsell, Amanda, Baron, Jody L., Maher, Jacquelyn J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584926/
https://ncbi.nlm.nih.gov/pubmed/28873429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183912
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