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Repression of the F-box protein Skp2 is essential for actin damage-induced tetraploid G1 arrest

We previously reported that p53 plays a role as a key regulator in the tetraploid G1 checkpoint, which is activated by actin damage-induced cytokinesis blockade and then prevents uncoupled DNA replication and nuclear division without cytokinesis. In this study, we investigated a role of Skp2, which...

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Библиографические подробности
Опубликовано в: :BMB Rep
Главные авторы: Jo, Yongsam, Shin, Deug Y.
Формат: Artigo
Язык:Inglês
Опубликовано: Korean Society for Biochemistry and Molecular Biology 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584746/
https://ncbi.nlm.nih.gov/pubmed/28648144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2017.50.7.063
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