Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation

The caseinolytic peptidase P (ClpP) is the endopeptidase component of the mitochondrial matrix ATP-dependent ClpXP protease. ClpP degrades unfolded proteins to maintain mitochondrial protein homeostasis and is involved in the initiation of the mitochondrial unfolded protein response (UPR(mt)). Outsi...

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Publicado no:Free Radic Biol Med
Main Authors: Deepa, Sathyaseelan S., Bhaskaran, Shylesh, Ranjit, Rojina, Qaisar, Rizwan, Nair, Binoj C., Liu, Yuhong, Walsh, Michael E., Fok, Wilson C., Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584630/
https://ncbi.nlm.nih.gov/pubmed/26721594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.12.021
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