Engineering Aglycosylated IgG Variants with Wild-type or Improved Binding Affinity to Human Fc gamma RIIA and Fc gamma RIIIAs

The binding of human IgG1 to human Fc gamma receptors (hFcγR) is highly sensitive to the presence of a single N-linked glycosylation site at asparagine 297 of the Fc, with deglycosylation resulting in a complete loss of hFcγR binding. Previously, we demonstrated that aglycosylated human IgG1 Fc vari...

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Pubblicato in:J Mol Biol
Autori principali: Chen, Tiffany F., Sazinsky, Stephen L., Houde, Damian, DiLillo, David J., Bird, Julie, Li, Kevin K., Cheng, George T., Qiu, Huawei, Engen, John R., Ravetch, Jeffrey V., Wittrup, K. Dane
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584586/
https://ncbi.nlm.nih.gov/pubmed/28694069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.07.001
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