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Aglycosylated immunoglobulin G(1) variants productively engage activating Fc receptors
Immunoglobulin G plays a vital role in adaptive immunity and antibody-based therapy through engagement of its Fc region by the Fcγ receptors (FcγRs) on immune cells. In addition to specific protein-protein contacts, N-linked glycosylation of the IgG Fc has been thought to be essential for the recogn...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629253/ https://ncbi.nlm.nih.gov/pubmed/19074274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809257105 |
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