Identification of novel small molecule Beclin 1 mimetics activating autophagy

Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free out Beclin 1, and thus trigger autophagy. In order to identify small molecule Be...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yu, Jia, Lan, Lan, Lewin, Seth J., Rogers, Steven A., Roy, Anuradha, Wu, Xiaoqing, Gao, Philip, Karanicolas, John, Aubé, Jeffrey, Sun, Baiwang, Xu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584254/
https://ncbi.nlm.nih.gov/pubmed/28881653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17977
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