EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway

Integrity of endothelial barrier is a determinant of the prognosis in the acute lung injury caused by sepsis. The epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, exhibit protective effects in various pathogenic states, however, whether EETs play a role in endothelial barrier enhan...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Dong, Ruolan, Hu, Danli, Yang, Yan, Chen, Zhihui, Fu, Menglu, Wang, Dao Wen, Xu, Xizhen, Tu, Ling
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584221/
https://ncbi.nlm.nih.gov/pubmed/28881620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17331
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