EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway

Integrity of endothelial barrier is a determinant of the prognosis in the acute lung injury caused by sepsis. The epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, exhibit protective effects in various pathogenic states, however, whether EETs play a role in endothelial barrier enhan...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Dong, Ruolan, Hu, Danli, Yang, Yan, Chen, Zhihui, Fu, Menglu, Wang, Dao Wen, Xu, Xizhen, Tu, Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584221/
https://ncbi.nlm.nih.gov/pubmed/28881620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17331
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