Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

We analyzed whole exome sequencing data in germline DNA from 412 high grade serous ovarian cancer (HGSOC) cases from The Cancer Genome Atlas Project and identified 5,517 genes harboring a predicted deleterious germline coding mutation in at least one HGSOC case. Gene-set enrichment analysis showed e...

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Pubblicato in:Oncotarget
Autori principali: Dicks, Ed, Song, Honglin, Ramus, Susan J., Oudenhove, Elke Van, Tyrer, Jonathan P., Intermaggio, Maria P., Kar, Siddhartha, Harrington, Patricia, Bowtell, David D., Group, AOCS Study, Cicek, Mine S., Cunningham, Julie M., Fridley, Brooke L., Alsop, Jennifer, Jimenez-Linan, Mercedes, Piskorz, Anna, Goranova, Teodora, Kent, Emma, Siddiqui, Nadeem, Paul, James, Crawford, Robin, Poblete, Samantha, Lele, Shashi, Sucheston-Campbell, Lara, Moysich, Kirsten B., Sieh, Weiva, McGuire, Valerie, Lester, Jenny, Odunsi, Kunle, Whittemore, Alice S., Bogdanova, Natalia, Dürst, Matthias, Hillemanns, Peter, Karlan, Beth Y., Gentry-Maharaj, Aleksandra, Menon, Usha, Tischkowitz, Marc, Levine, Douglas, Brenton, James D., Dörk, Thilo, Goode, Ellen L., Gayther, Simon A., Pharoah, D.P. Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584218/
https://ncbi.nlm.nih.gov/pubmed/28881617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15871
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