PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations

Mosaic truncating mutations in the protein phosphatase, Mg(2+)/Mn(2+)-dependent, 1D (PPM1D) gene have recently been reported with a statistically significantly greater frequency in lymphocyte DNA from ovarian cancer case patients compared with unaffected control patients. Using massively parallel se...

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Publicat a:J Natl Cancer Inst
Autors principals: Pharoah, Paul D. P., Song, Honglin, Dicks, Ed, Intermaggio, Maria P., Harrington, Patricia, Baynes, Caroline, Alsop, Kathryn, Bogdanova, Natalia, Cicek, Mine S., Cunningham, Julie M., Fridley, Brooke L., Gentry-Maharaj, Aleksandra, Hillemanns, Peter, Lele, Shashi, Lester, Jenny, McGuire, Valerie, Moysich, Kirsten B., Poblete, Samantha, Sieh, Weiva, Sucheston-Campbell, Lara, Widschwendter, Martin, Whittemore, Alice S., Dörk, Thilo, Menon, Usha, Odunsi, Kunle, Goode, Ellen L., Karlan, Beth Y., Bowtell, David D., Gayther, Simon A., Ramus, Susan J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072371/
https://ncbi.nlm.nih.gov/pubmed/26823519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv347
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