The miR-106a~363(Xpcl1) miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27(Kip1) cell cycle inhibitor

The miR-106a~363 cluster encodes 6 miRNAs on the X-chromosome which are abundant in blood cells and overexpressed in a variety of malignancies. The constituent miRNA of miR-106a~363 have functional activities in vitro that are predicted to be both oncogenic and tumor suppressive, yet little is known...

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Pubblicato in:Oncotarget
Autori principali: Kuppers, Daniel A., Schmitt, Thomas M., Hwang, Harry C., Samraj, Lavanya, Clurman, Bruce E., Fero, Matthew L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584189/
https://ncbi.nlm.nih.gov/pubmed/28881594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16932
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