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Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover

Cell motility depends on tight coordination between the microtubule (MT) and actin cytoskeletons, but the mechanisms underlying this MT–actin cross talk have remained poorly understood. Here, we show that the tumor suppressor protein adenomatous polyposis coli (APC), which is a known MT-associated p...

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Опубликовано в: :J Cell Biol
Главные авторы: Juanes, M. Angeles, Bouguenina, Habib, Eskin, Julian A., Jaiswal, Richa, Badache, Ali, Goode, Bruce L.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584174/
https://ncbi.nlm.nih.gov/pubmed/28663347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201702007
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