A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus

Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies, which include partial lipodystrophies associated with metabolic syndromes. The lipodystrophy-associated LMNA p.R482W mutation is known to impair adipogenic differentiation, but the mechanisms involved are unclear. We s...

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Publicat a:J Cell Biol
Autors principals: Oldenburg, Anja, Briand, Nolwenn, Sørensen, Anita L., Cahyani, Inswasti, Shah, Akshay, Moskaug, Jan Øivind, Collas, Philippe
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584164/
https://ncbi.nlm.nih.gov/pubmed/28751304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701043
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