CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

Effective targeting of cancer stem cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both of these phenotypes via CD55, an intrinsic cell surface complement inhibit...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Saygin, Caner, Wiechert, Andrew, Rao, Vinay S., Alluri, Ravi, Connor, Elizabeth, Thiagarajan, Praveena S., Hale, James S., Li, Yan, Chumakova, Anastasia, Jarrar, Awad, Parker, Yvonne, Lindner, Daniel J., Nagaraj, Anil Belur, Kim, J. Julie, DiFeo, Analisa, Abdul-Karim, Fadi W., Michener, Chad, Rose, Peter G., DeBernardo, Robert, Mahdi, Haider, McCrae, Keith R., Lin, Feng, Lathia, Justin D., Reizes, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584126/
https://ncbi.nlm.nih.gov/pubmed/28838952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170438
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