CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

Effective targeting of cancer stem cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both of these phenotypes via CD55, an intrinsic cell surface complement inhibit...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Saygin, Caner, Wiechert, Andrew, Rao, Vinay S., Alluri, Ravi, Connor, Elizabeth, Thiagarajan, Praveena S., Hale, James S., Li, Yan, Chumakova, Anastasia, Jarrar, Awad, Parker, Yvonne, Lindner, Daniel J., Nagaraj, Anil Belur, Kim, J. Julie, DiFeo, Analisa, Abdul-Karim, Fadi W., Michener, Chad, Rose, Peter G., DeBernardo, Robert, Mahdi, Haider, McCrae, Keith R., Lin, Feng, Lathia, Justin D., Reizes, Ofer
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584126/
https://ncbi.nlm.nih.gov/pubmed/28838952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170438
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