S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

Metastasis is the primary cause of cancer death. The inflammatory tumor microenvironment contributes to metastasis, for instance, by recruiting blood and lymph vessels. Among tumor-infiltrating immune cells, tumor-associated macrophages (TAMs) take a center stage in promoting both tumor angiogenesis...

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Publicat a:J Exp Med
Autors principals: Weichand, Benjamin, Popp, Rüdiger, Dziumbla, Sarah, Mora, Javier, Strack, Elisabeth, Elwakeel, Eiman, Frank, Ann-Christin, Scholich, Klaus, Pierre, Sandra, Syed, Shahzad N., Olesch, Catherine, Ringleb, Julia, Ören, Bilge, Döring, Claudia, Savai, Rajkumar, Jung, Michaela, von Knethen, Andreas, Levkau, Bodo, Fleming, Ingrid, Weigert, Andreas, Brüne, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584110/
https://ncbi.nlm.nih.gov/pubmed/28739604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160392
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