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Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor growth and metastasis, largely on the basis of overexpression studies and the application of exogenous epoxides. Here we studied tumor growth and metastasis in Cyp2c44(−/−) mice crossed onto the...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Kesavan, Rushendhiran, Frömel, Timo, Zukunft, Sven, Laban, Hebatullah, Geyer, Alexandra, Naeem, Zumer, Heidler, Juliana, Wittig, Ilka, Elwakeel, Eiman, Brüne, Bernhard, Weigert, Andreas, Popp, Rüdiger, Fleming, Ingrid
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084120/
https://ncbi.nlm.nih.gov/pubmed/32123095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921381117
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