Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor growth and metastasis, largely on the basis of overexpression studies and the application of exogenous epoxides. Here we studied tumor growth and metastasis in Cyp2c44(−/−) mice crossed onto the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kesavan, Rushendhiran, Frömel, Timo, Zukunft, Sven, Laban, Hebatullah, Geyer, Alexandra, Naeem, Zumer, Heidler, Juliana, Wittig, Ilka, Elwakeel, Eiman, Brüne, Bernhard, Weigert, Andreas, Popp, Rüdiger, Fleming, Ingrid
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084120/
https://ncbi.nlm.nih.gov/pubmed/32123095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921381117
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