Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133(+)/EpCAM(+) phenotype: a promising target for preventing progression of TNBC

BACKGROUND: The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate with breast tumor aggressiveness, suggesting that simultaneous targeting of th...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Brugnoli, Federica, Grassilli, Silvia, Lanuti, Paola, Marchisio, Marco, Al-Qassab, Yasamin, Vezzali, Federica, Capitani, Silvano, Bertagnolo, Valeria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584040/
https://ncbi.nlm.nih.gov/pubmed/28870198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3592-y
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