Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy(1). To develop candidate therapeutic agents against ZIKV, we isolated a panel of human monoclonal antibodies from subjects that were previously infected...

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Pubblicato in:Nature
Autori principali: Sapparapu, Gopal, Fernandez, Estefania, Kose, Nurgun, Cao, Bin, Fox, Julie M., Bombardi, Robin G., Zhao, Haiyan, Nelson, Christopher A., Bryan, Aubrey L., Barnes, Trevor, Davidson, Edgar, Mysorekar, Indira U., Fremont, Daved H., Doranz, Benjamin J., Diamond, Michael S., Crowe, James E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583716/
https://ncbi.nlm.nih.gov/pubmed/27819683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20564
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