Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge

We previously generated a panel of human monoclonal antibodies (mAbs) against Zika virus (ZIKV) and identified one, ZIKV-116, that shares germline usage with mAbs identified in multiple donors. Here we show that ZIKV-116 interferes with ZIKV infection at a post-cellular attachment step by blocking v...

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Vydáno v:J Exp Med
Hlavní autoři: Zhao, Haiyan, Xu, Lily, Bombardi, Robin, Nargi, Rachel, Deng, Zengqin, Errico, John M., Nelson, Christopher A., Dowd, Kimberly A., Pierson, Theodore C., Crowe, James E., Diamond, Michael S., Fremont, Daved H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041715/
https://ncbi.nlm.nih.gov/pubmed/31757867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191792
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