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Rapid LC-MS Based High-Throughput Screening Method, Affording No False Positives or False Negatives, Identifies a New Inhibitor for Carbonic Anhydrase

Developing effective high-throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. While rugged and robust assays may be easily developed for certain enzymes, HTS assays designed to identify ligands that block protein binding are much more challenging to de...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Imaduwage, Kasun P., Lakbub, Jude, Go, Eden P., Desaire, Heather
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583356/
https://ncbi.nlm.nih.gov/pubmed/28871149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08602-w
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