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Rapid LC-MS Based High-Throughput Screening Method, Affording No False Positives or False Negatives, Identifies a New Inhibitor for Carbonic Anhydrase

Developing effective high-throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. While rugged and robust assays may be easily developed for certain enzymes, HTS assays designed to identify ligands that block protein binding are much more challenging to de...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Imaduwage, Kasun P., Lakbub, Jude, Go, Eden P., Desaire, Heather
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583356/
https://ncbi.nlm.nih.gov/pubmed/28871149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08602-w
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