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A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis

Protein-bound uremic toxins (PBUTs) are difficult to remove by conventional hemodialysis; a high degree of protein binding reduces the free fraction of toxins and decreases their diffusion across dialyzer membranes. Mechanistic understanding of PBUT kinetics can open new avenues to improve their dia...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Maheshwari, Vaibhav, Thijssen, Stephan, Tao, Xia, Fuertinger, Doris, Kappel, Franz, Kotanko, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583320/
https://ncbi.nlm.nih.gov/pubmed/28871178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10981-z
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