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A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis
Hemodialysis (HD) has limited efficacy towards treatment of drug toxicity due to strong drug-protein binding. In this work, we propose to infuse a competitor drug into the extracorporeal circuit that increases the free fraction of a toxic drug and thereby increases its dialytic removal. We used a me...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7347918/ https://ncbi.nlm.nih.gov/pubmed/32647294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68333-3 |
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