The phytochemical 3,3′-Diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells

Androgen receptor (AR) is a nuclear receptor transcription factor that plays a central role in normal prostate physiology as well as in prostate cancer biology (PCa). Phytochemicals like 3,3′-Diindolylmethane (DIM) have emerged as promising therapeutic agents against PCa. DIM has been shown to influ...

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Vydáno v:J Nutr Biochem
Hlavní autoři: Palomera-Sanchez, Zoraya, Watson, Gregory W., Wong, Carmen P., Beaver, Laura M., Williams, David E., Dashwood, Roderick H., Ho, Emily
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583029/
https://ncbi.nlm.nih.gov/pubmed/28582660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2017.05.005
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