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The phytochemical 3,3′-Diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells
Androgen receptor (AR) is a nuclear receptor transcription factor that plays a central role in normal prostate physiology as well as in prostate cancer biology (PCa). Phytochemicals like 3,3′-Diindolylmethane (DIM) have emerged as promising therapeutic agents against PCa. DIM has been shown to influ...
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| Publicado no: | J Nutr Biochem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5583029/ https://ncbi.nlm.nih.gov/pubmed/28582660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2017.05.005 |
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