Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

Most Foxp3(+) regulatory T (T(reg)) cells develop in the thymus as a functionally mature T cell subpopulation specialized for immune suppression. Their cell fate appears to be determined before Foxp3 expression; yet molecular events that prime Foxp3(−) T(reg) precursor cells are largely obscure. We...

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Udgivet i:Nat Immunol
Main Authors: Kitagawa, Yohko, Ohkura, Naganari, Kidani, Yujiro, Vandenbon, Alexis, Hirota, Keiji, Kawakami, Ryoji, Yasuda, Keiko, Motooka, Daisuke, Nakamura, Shota, Kondo, Motonari, Taniuchi, Ichiro, Kohwi-Shigematsu, Terumi, Sakaguchi, Shimon
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582804/
https://ncbi.nlm.nih.gov/pubmed/27992401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3646
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