PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in the pathogenesis of OA, the exact mechanism under...

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Udgivet i:Redox Biol
Main Authors: Ma, Ching-Hou, Wu, Chin-Hsien, Jou, I.-Ming, Tu, Yuan-Kun, Hung, Ching-Hsia, Hsieh, Pei-Ling, Tsai, Kun-Ling
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582648/
https://ncbi.nlm.nih.gov/pubmed/28869834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.08.011
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