Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism. Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are two critical sensors that regulate mitochondrial biogenesis and have been recognized as...

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Bibliografiske detaljer
Udgivet i:Redox Biol
Main Authors: Ma, Ching-Hou, Chiua,, Yen Chun, Wu, Chin-Hsien, Jou, I.-Ming, Tu, Yuan-Kun, Hung, Ching-Hsia, Hsieh, Pei-Ling, Tsai, Kun-Ling
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881416/
https://ncbi.nlm.nih.gov/pubmed/29413962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.01.010
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