AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells

Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2...

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Опубликовано в: :Hum Gene Ther
Главные авторы: Sanchez, Anamaria C., Li, Chengwen, Andrews, Barbara, Asenjo, Juan A., Samulski, R. Jude
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc. 2017
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582589/
https://ncbi.nlm.nih.gov/pubmed/28578603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.043
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