AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells

Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Sanchez, Anamaria C., Li, Chengwen, Andrews, Barbara, Asenjo, Juan A., Samulski, R. Jude
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582589/
https://ncbi.nlm.nih.gov/pubmed/28578603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.043
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