AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells

Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2...

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Bibliografski detalji
Izdano u:Hum Gene Ther
Glavni autori: Sanchez, Anamaria C., Li, Chengwen, Andrews, Barbara, Asenjo, Juan A., Samulski, R. Jude
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2017
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582589/
https://ncbi.nlm.nih.gov/pubmed/28578603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.043
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