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Fertile offspring from sterile sex chromosome trisomic mice

Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy (SCT) affects 0.1% of the human population and is associated with infertility. We show that during reprogramming to induced pluripotent stem cells (iPSC), fibroblasts from sterile trisomic XXY...

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Bibliografiske detaljer
Udgivet i:Science
Main Authors: Hirota, Takayuki, Ohta, Hiroshi, Powell, Benjamin E., Mahadevaiah, Shantha K., Ojarikre, Obah A., Saitou, Mitinori, Turner, James M. A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581950/
https://ncbi.nlm.nih.gov/pubmed/28818972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam9046
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