SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice

Meiotic synapsis and recombination ensure correct homologous segregation and genetic diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which serves a surveillance function and in males drives meiotic sex chromosome inactivation. Silencing depends on the DNA damage...

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Bibliographic Details
Published in:Dev Cell
Main Authors: Hirota, Takayuki, Blakeley, Paul, Sangrithi, Mahesh N., Mahadevaiah, Shantha K., Encheva, Vesela, Snijders, Ambrosius P., ElInati, Elias, Ojarikre, Obah A., de Rooij, Dirk G., Niakan, Kathy K., Turner, James M.A.
Format: Artigo
Language:Inglês
Published: Cell Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286383/
https://ncbi.nlm.nih.gov/pubmed/30393076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.10.004
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