SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice

Meiotic synapsis and recombination ensure correct homologous segregation and genetic diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which serves a surveillance function and in males drives meiotic sex chromosome inactivation. Silencing depends on the DNA damage...

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Publicado en:Dev Cell
Main Authors: Hirota, Takayuki, Blakeley, Paul, Sangrithi, Mahesh N., Mahadevaiah, Shantha K., Encheva, Vesela, Snijders, Ambrosius P., ElInati, Elias, Ojarikre, Obah A., de Rooij, Dirk G., Niakan, Kathy K., Turner, James M.A.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286383/
https://ncbi.nlm.nih.gov/pubmed/30393076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.10.004
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