Ribonucleotide reductase large subunit (RRM1) as a novel therapeutic target in multiple myeloma

PURPOSE: To investigate the biologic and clinical significance of ribonucleotide reductase (RR) in multiple myeloma (MM). EXPERIMENTAL DESIGN: We assessed the impact of RR expression on patient outcome in MM. We then characterized the effect of genetic and pharmacological inhibition of RRM1 on MM gr...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Sagawa, Morihiko, Ohguchi, Hiroto, Harada, Takeshi, Samur, Mehmet K., Tai, Yu-Tzu, Munshi, Nikhil C., Kizaki, Masahiro, Hideshima, Teru, Anderson, Kenneth C.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581671/
https://ncbi.nlm.nih.gov/pubmed/28442502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0263
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