Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson’s disease

Alpha-synuclein (aS) amyloid formation is involved in Parkinson’s disease (PD); therefore, small molecules that target aS and affect its aggregation are of interest as future drug candidates. We recently reported modified ring-fused 2-pyridones that modulate aS amyloid formation in vitro. Here, we d...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Pokrzywa, Małgorzata, Pawełek, Katarzyna, Kucia, Weronika Elżbieta, Sarbak, Szymon, Chorell, Erik, Almqvist, Fredrik, Wittung-Stafshede, Pernilla
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581160/
https://ncbi.nlm.nih.gov/pubmed/28863169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184117
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