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Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice
The assembly process of α-synuclein toward amyloid fibers is linked to neurodegeneration in Parkinson’s disease. In the present study, we capitalized on the in vitro discovery of a small-molecule accelerator of α-synuclein amyloid formation and assessed its effects when injected in brains of normal...
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| Publicat a: | NPJ Parkinsons Dis |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5516562/ https://ncbi.nlm.nih.gov/pubmed/28725689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjparkd.2015.24 |
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