Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1

Abnormal osteoclast activation contributes to osteolytic bone diseases (OBDs). It was reported that curdlan, an agonist of dectin-1, inhibits osteoclastogenesis. However, the underlying mechanisms are not fully elucidated. In this study, we found that curdlan potently inhibited RANKL-induced osteocl...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Zhu, Xiaoqing, Zhao, Yinghua, Jiang, Yuxue, Qin, Tianxue, Chen, Jintong, Chu, Xiao, Yi, Qing, Gao, Sujun, Wang, Siqing
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581116/
https://ncbi.nlm.nih.gov/pubmed/28881817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18411
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