The Dectin 1 Agonist Curdlan Regulates Osteoclastogenesis by Inhibiting Nuclear Factor of Activated T cells Cytoplasmic 1 (NFATc1) through Syk Kinase

Several immune system cell surface receptors are reported to be associated with osteoclastogenesis. Dectin 1, a lectin receptor for β-glucan, is found predominantly on cells of the myeloid lineage. In this study, we examined the effect of the dectin 1 agonist curdlan on osteoclastogenesis. In mouse...

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Main Authors: Yamasaki, Toru, Ariyoshi, Wataru, Okinaga, Toshinori, Adachi, Yoshiyuki, Hosokawa, Ryuji, Mochizuki, Shinichi, Sakurai, Kazuo, Nishihara, Tatsuji
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081954/
https://ncbi.nlm.nih.gov/pubmed/24821724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551416
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