The anti-ErbB2 antibody H2-18 and the pan-PI3K inhibitor GDC-0941 effectively inhibit trastuzumab-resistant ErbB2-overexpressing breast cancer

Trastuzumab, an anti-ErbB2 humanized antibody, brings benefit to patients with ErbB2-amplified metastatic breast cancers. However, the resistance to trastuzumab is common. Our previously reported H2-18, an anti-ErbB2 antibody, potently induced programmed cell death in trastuzumab-resistant breast ca...

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Udgivet i:Oncotarget
Main Authors: Wang, Lingfei, Yu, Xiaojie, Wang, Chao, Pan, Shujun, Liang, Beibei, Zhang, Yajun, Chong, Xiaodan, Meng, Yanchun, Dong, Jian, Zhao, Yirong, Yang, Yang, Wang, Huajing, Gao, Jie, Wei, Huafeng, Zhao, Jian, Wang, Hao, Hu, Chaohua, Xiao, Wenze, Li, Bohua
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581078/
https://ncbi.nlm.nih.gov/pubmed/28881779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17907
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