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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

Efficient delivery of oligonucleotide therapeutics, i.e., siRNAs, to the central nervous system represents a significant barrier to their clinical advancement for the treatment of neurological disorders. Small, endogenous extracellular vesicles were shown to be able to transport lipids, proteins and...

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Dades bibliogràfiques
Publicat a:Bio Protoc
Autors principals: Haraszti, Reka A., Coles, Andrew, Aronin, Neil, Khvorova, Anastasia, Didiot, Marie-Cécile
Format: Artigo
Idioma:Inglês
Publicat: Bio-Protocol 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580947/
https://ncbi.nlm.nih.gov/pubmed/28868334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2338
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