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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

Efficient delivery of oligonucleotide therapeutics, i.e., siRNAs, to the central nervous system represents a significant barrier to their clinical advancement for the treatment of neurological disorders. Small, endogenous extracellular vesicles were shown to be able to transport lipids, proteins and...

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Bibliografische gegevens
Gepubliceerd in:Bio Protoc
Hoofdauteurs: Haraszti, Reka A., Coles, Andrew, Aronin, Neil, Khvorova, Anastasia, Didiot, Marie-Cécile
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Bio-Protocol 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580947/
https://ncbi.nlm.nih.gov/pubmed/28868334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2338
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