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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

Efficient delivery of oligonucleotide therapeutics, i.e., siRNAs, to the central nervous system represents a significant barrier to their clinical advancement for the treatment of neurological disorders. Small, endogenous extracellular vesicles were shown to be able to transport lipids, proteins and...

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Bibliografski detalji
Izdano u:Bio Protoc
Glavni autori: Haraszti, Reka A., Coles, Andrew, Aronin, Neil, Khvorova, Anastasia, Didiot, Marie-Cécile
Format: Artigo
Jezik:Inglês
Izdano: Bio-Protocol 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580947/
https://ncbi.nlm.nih.gov/pubmed/28868334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2338
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