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Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies
Cytoplasmic TDP-43 mislocalization and aggregation is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is an RNA-binding protein (RBP) with a prion-like domain (PrLD) that promotes TDP-43 misfolding. PrLDs possess compositional similarity to cano...
Shranjeno v:
| izdano v: | Cold Spring Harb Perspect Med |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5580514/ https://ncbi.nlm.nih.gov/pubmed/27920024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024554 |
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