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A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals. Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo. Here we present a highly sensitive assay that recapitulates native CLOCK-BM...
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| Yayımlandı: | F1000Res |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
F1000Research
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5580408/ https://ncbi.nlm.nih.gov/pubmed/28928952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.11685.2 |
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