Loss of Apela peptide in mice causes low penetrance embryonic lethality and defects in early mesodermal derivatives

Apela (also known as Elabela, Ende and Toddler) is a small signaling peptide that activates the G protein-coupled receptor Aplnr to stimulate cell migration during zebrafish gastrulation. Here, using CRISPR/Cas9 to generate a null, reporter-expressing allele, we study the role of Apela in the develo...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Freyer, Laina, Hsu, Chih-Wei, Nowotschin, Sonja, Pauli, Andrea, Ishida, Junji, Kuba, Keiji, Fukamizu, Akiyoshi, Schier, Alexander F., Hoodless, Pamela A., Dickinson, Mary E., Hadjantonakis, Anna-Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580402/
https://ncbi.nlm.nih.gov/pubmed/28854362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.014
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