Inhibitors of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair

The enzyme 15-prostaglandin dehydrogenase (15-PGDH) catalyzes the first step in the degradation of prostaglandins including PGE2. It is a negative regulator of tissue repair and regeneration in multiple organs. Accordingly, inhibitors of 15-PGDH are anticipated to elevate in vivo levels of PGE2 and...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Antczak, Monika I., Zhang, Yongyou, Wang, Changguang, Doran, Jennifer, Naidoo, Jacinth, Voruganti, Sukesh, Williams, Noelle S., Markowitz, Sanford D., Ready, Joseph M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580352/
https://ncbi.nlm.nih.gov/pubmed/28398755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00271
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