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Inhibitors of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair
The enzyme 15-prostaglandin dehydrogenase (15-PGDH) catalyzes the first step in the degradation of prostaglandins including PGE2. It is a negative regulator of tissue repair and regeneration in multiple organs. Accordingly, inhibitors of 15-PGDH are anticipated to elevate in vivo levels of PGE2 and...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5580352/ https://ncbi.nlm.nih.gov/pubmed/28398755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00271 |
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