Sparse conserved under-methylated CpGs are associated with high-order chromatin structure

BACKGROUND: Whole-genome bisulfite sequencing (WGBS) is the gold standard for studying landscape DNA methylation. Current computational methods for WGBS are mainly designed for gene regulatory regions with multiple under-methylated CpGs (UMCs), such as promoters and enhancers. RESULTS: To reliably p...

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Bibliographic Details
Published in:Genome Biol
Main Authors: Lin, Xueqiu, Su, Jianzhong, Chen, Kaifu, Rodriguez, Benjamin, Li, Wei
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580327/
https://ncbi.nlm.nih.gov/pubmed/28859663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1296-x
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