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Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling

In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased th...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Kim, Ji Cheol, Jung, Young Su, Lee, Ha Young, Park, Joon Seong, Bae, Yoe-Sik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579511/
https://ncbi.nlm.nih.gov/pubmed/28857084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.120
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